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Sugi Predict / Compounds / SCHEMBL16287072

SCHEMBL16287072

SCHEMBL16287072

Cn1c(=O)c(-c2c(Cl)cccc2Cl)cc2c(N)nc(Nc3ccc(NCCN4CCOCC4)cc3)nc21

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ SRC P12931 15/20 0.59
▸ FGFR1 P11362 14/20 0.59
▸ FGFR2 P21802 3/20 0.59
▸ FGFR4 P22455 3/20 0.59
▸ FGFR3 P22607 3/20 0.59
▸ PDGFRB P09619 8/20 0.57
▸ PDGFRA P16234 8/20 0.57
▸ SLC2A1 P11166 1/20 0.57
▸ PKMYT1 Q99640 1/20 0.57
▸ WEE1 P30291 1/20 0.53
▸ ABL1 P00519 7/20 0.52
▸ MAPK14 Q16539 7/20 0.52
▸ KIT P10721 4/20 0.52
▸ EGFR P00533 5/20 0.50
▸ MAPK8 P45983 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16287461 0.88 FGFR1 (0.66) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL16287869 0.83 SRC (0.73) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL16287371 0.83 SRC (0.74) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL16287539 0.82 WEE1 (0.69) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL16287166 0.81 SRC (0.62) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL16287053 0.79 SRC (0.69) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL5762069 0.74 FGFR1 (1.00) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL16986361 0.73 FGFR1 (0.59) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL29508114 0.73 SRC (1.00) SRCFGFR1FGFR2FGFR4FGFR3
SCHEMBL3458816 0.73 SRC (1.00) SRCFGFR1FGFR2FGFR4FGFR3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9630962-B2 4-amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof HOSPITAL CLINIC DE BARCELONA (ES) 2017-04-25 — — US claimed
EP-3008063-B1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO(2,3-D)PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INST QUÍMIC DE SARRIÁ CETS FUNDACIÓ PRIVADA (ES) 2017-04-19 — — EP claimed
US-20160176866-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ, PRIVADA (ES) 2016-06-23 — — US claimed
EP-3008063-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF Institut Químic de Sarriá CETS Fundació Privada (ES) 2016-04-20 — — EP claimed
WO-2014198960-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ PRIVADA (ES) 2014-12-18 — — WO claimed
EP-2813504-A1 4-Amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof Institut Quimic De Sarriá Cets, Fundació Privada (ES) 2014-12-17 — — EP claimed
US-9630962-B2 4-amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof HOSPITAL CLINIC DE BARCELONA (ES) 2017-04-25 — — US disclosed
US-9630962-B2 4-amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof HOSPITAL CLINIC DE BARCELONA (ES) 2017-04-25 — — US disclosed
EP-3008063-B1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO(2,3-D)PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INST QUÍMIC DE SARRIÁ CETS FUNDACIÓ PRIVADA (ES) 2017-04-19 — — EP disclosed
EP-3008063-B1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO(2,3-D)PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INST QUÍMIC DE SARRIÁ CETS FUNDACIÓ PRIVADA (ES) 2017-04-19 — — EP disclosed
US-20160176866-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ, PRIVADA (ES) 2016-06-23 — — US disclosed
US-20160176866-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ, PRIVADA (ES) 2016-06-23 — — US disclosed
WO-2014198960-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ PRIVADA (ES) 2014-12-18 — — WO disclosed
EP-2813504-A1 4-Amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof Institut Quimic De Sarriá Cets, Fundació Privada (ES) 2014-12-17 — — EP disclosed
EP-2813504-A1 4-Amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof Institut Quimic De Sarriá Cets, Fundació Privada (ES) 2014-12-17 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160176866-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF BCL6, BCL9, BCL3 SRC 1641/4885FGFR1 4256/4885FGFR2 3560/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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