Sugi Predict

Sugi Predict / Compounds / SCHEMBL16287793

SCHEMBL16287793

SCHEMBL16287793

Nc1nc(Nc2ccccc2)nc2c1cc(-c1c(Cl)cccc1Cl)c(=O)n2Cc1ccccc1

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 7/20 0.56
▸ EGFR P00533 5/20 0.56
▸ RIPK2 O43353 1/20 0.52
▸ ACVR1 Q04771 1/20 0.52
▸ NOD2 Q9HC29 1/20 0.52
▸ WEE1 P30291 8/20 0.51
▸ SRC P12931 5/20 0.51
▸ FGFR2 P21802 2/20 0.51
▸ FGFR4 P22455 2/20 0.51
▸ FGFR3 P22607 2/20 0.51
▸ ABL1 P00519 4/20 0.46
▸ PDGFRB P09619 4/20 0.46
▸ PDGFRA P16234 4/20 0.46
▸ MAPK14 Q16539 4/20 0.46
▸ KIT P10721 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16986362 0.90 FGFR1 (0.69) FGFR1EGFRRIPK2ACVR1NOD2
SCHEMBL16986353 0.88 FGFR1 (0.54) FGFR1EGFRWEE1SRCFGFR2
SCHEMBL16986361 0.88 FGFR1 (0.59) FGFR1EGFRWEE1SRCFGFR2
SCHEMBL16986360 0.87 FGFR1 (0.55) FGFR1EGFRRIPK2ACVR1NOD2
SCHEMBL16986341 0.87 FGFR1 (0.57) FGFR1EGFRWEE1SRCFGFR2
SCHEMBL16986305 0.86 RIPK2 (0.55) FGFR1EGFRRIPK2ACVR1NOD2
SCHEMBL16287539 0.85 WEE1 (0.69) FGFR1EGFRWEE1SRCFGFR2
SCHEMBL16287869 0.78 SRC (0.73) FGFR1EGFRRIPK2ACVR1NOD2
SCHEMBL16287166 0.77 SRC (0.62) FGFR1EGFRRIPK2ACVR1NOD2
SCHEMBL16287646 0.75 NPC1 (0.45) FGFR1EGFRWEE1SRCFGFR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9630962-B2 4-amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof HOSPITAL CLINIC DE BARCELONA (ES) 2017-04-25 — — US claimed
EP-3008063-B1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO(2,3-D)PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INST QUÍMIC DE SARRIÁ CETS FUNDACIÓ PRIVADA (ES) 2017-04-19 — — EP claimed
US-20160176866-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ, PRIVADA (ES) 2016-06-23 — — US claimed
EP-3008063-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF Institut Químic de Sarriá CETS Fundació Privada (ES) 2016-04-20 — — EP claimed
WO-2014198960-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ PRIVADA (ES) 2014-12-18 — — WO claimed
EP-2813504-A1 4-Amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof Institut Quimic De Sarriá Cets, Fundació Privada (ES) 2014-12-17 — — EP claimed
US-9630962-B2 4-amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof HOSPITAL CLINIC DE BARCELONA (ES) 2017-04-25 — — US disclosed
US-9630962-B2 4-amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof HOSPITAL CLINIC DE BARCELONA (ES) 2017-04-25 — — US disclosed
EP-3008063-B1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO(2,3-D)PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INST QUÍMIC DE SARRIÁ CETS FUNDACIÓ PRIVADA (ES) 2017-04-19 — — EP disclosed
EP-3008063-B1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO(2,3-D)PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INST QUÍMIC DE SARRIÁ CETS FUNDACIÓ PRIVADA (ES) 2017-04-19 — — EP disclosed
US-20160176866-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ, PRIVADA (ES) 2016-06-23 — — US disclosed
US-20160176866-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ, PRIVADA (ES) 2016-06-23 — — US disclosed
WO-2014198960-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF INSTITUT QUÍMIC DE SARRIÁ, CETS FUNDACIÓ PRIVADA (ES) 2014-12-18 — — WO disclosed
EP-2813504-A1 4-Amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof Institut Quimic De Sarriá Cets, Fundació Privada (ES) 2014-12-17 — — EP disclosed
EP-2813504-A1 4-Amino-6-(2,6-dichlorophenyl)-2-(phenylamino)-pyrido[2,3-d]pyrimidin-7(8H)-one derivatives, synthesis and uses thereof Institut Quimic De Sarriá Cets, Fundació Privada (ES) 2014-12-17 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160176866-A1 4-AMINO-6-(2,6-DICHLOROPHENYL)-2-(PHENYLAMINO)-PYRIDO[2,3-d]PYRIMIDIN-7(8H)-ONE DERIVATIVES, SYNTHESIS AND USES THEREOF BCL6, BCL9, BCL3 FGFR1 4256/4885EGFR 3327/4885RIPK2 3664/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback