Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 14/20 | 0.69 |
| ▸ | PDE11A | Q9HCR9 | 3/20 | 0.43 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1629132 | 0.87 | HSP90AA1 (0.56) | HSP90AA1PDE11ANR3C2HSP90AB1 | |
| SCHEMBL1219136 | 0.87 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1 | |
| SCHEMBL2076846 | 0.87 | HSP90AA1 (0.61) | HSP90AA1PDE11ANR3C2HSP90AB1 | |
| SCHEMBL1630247 | 0.87 | HSP90AA1 (0.56) | HSP90AA1PDE11ANR3C2HSP90AB1 | |
| SCHEMBL1219237 | 0.87 | HSP90AA1 (0.61) | HSP90AA1PDE11ANR3C2HSP90AB1 | |
| SCHEMBL1629017 | 0.87 | HSP90AA1 (0.70) | HSP90AA1PDE11AHTR2AHTR2CSLC6A4 | |
| SCHEMBL1219192 | 0.85 | HSP90AA1 (0.60) | HSP90AA1HSP90AB1 | |
| SCHEMBL1219578 | 0.85 | HSP90AA1 (0.57) | HSP90AA1PDE11ANR3C2HSP90AB1 | |
| SCHEMBL1217333 | 0.85 | HSP90AA1 (0.59) | HSP90AA1PDE11ANR3C2HSP90AB1 | |
| SCHEMBL2080816 | 0.85 | HSP90AA1 (0.61) | HSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1776346-B1 | 1,5-Diphenylpyrazoles | MERCK PATENT GMBH (DE) | 2013-06-26 | — | — | EP | claimed |
| US-7932401-B2 | Heat Shock Protein 90 (HSP90) inhibitors; 5-(2-hydroxy-4-methoxyphenyl)-1-(3-nitrophenyl)-1H-pyrazole for example; antitumor agent, viral diseases, transplant rejection, cystic fibrosis, angiogenesis inhibition, infectious, autoimmune, or inflammatory diseases, ischemia, chemotherapy cytoprotectant | MERCK PATENT GMBH (DE) | 2011-04-26 | — | — | US | claimed |
| US-20080085904-A1 | 1,5-Diphenylpyrazoles | MERCK PATENT GMBH (DE) | 2008-04-10 | — | — | US | claimed |
| EP-1776346-B1 | 1,5-Diphenylpyrazoles | MERCK PATENT GMBH (DE) | 2013-06-26 | — | — | EP | disclosed |
| US-7932401-B2 | Heat Shock Protein 90 (HSP90) inhibitors; 5-(2-hydroxy-4-methoxyphenyl)-1-(3-nitrophenyl)-1H-pyrazole for example; antitumor agent, viral diseases, transplant rejection, cystic fibrosis, angiogenesis inhibition, infectious, autoimmune, or inflammatory diseases, ischemia, chemotherapy cytoprotectant | MERCK PATENT GMBH (DE) | 2011-04-26 | — | — | US | disclosed |
| US-20080085904-A1 | 1,5-Diphenylpyrazoles | MERCK PATENT GMBH (DE) | 2008-04-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080085904-A1 | 1,5-Diphenylpyrazoles | HSP90AB1, HSP90AA1, HSP90AB2P | HSP90AA1 2/4885PDE11A 4692/4885NR3C2 558/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.