Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.38 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.38 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.37 |
| ▸ | CCR4 | P51679 | 3/20 | 0.37 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 4/20 | 0.36 |
| ▸ | KDM5A | P29375 | 3/20 | 0.36 |
| ▸ | KDM5C | P41229 | 3/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.36 |
| ▸ | KDM5D | Q9BY66 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16293035 | 1.00 | CHRM2 (0.43) | CHRM2S1PR1HSP90AA1HSP90AB1SIRT2 | |
| SCHEMBL16293037 | 0.85 | CHRM2 (0.44) | CHRM2S1PR1HSP90AA1HSP90AB1SIRT2 | |
| SCHEMBL15994215 | 0.83 | CHRM2 (0.42) | CHRM2S1PR1HSP90AA1HSP90AB1SIRT2 | |
| SCHEMBL18880300 | 0.83 | CHRM2 (0.42) | CHRM2S1PR1HSP90AA1HSP90AB1SIRT2 | |
| SCHEMBL16006930 | 0.82 | CHRM2 (0.41) | CHRM2S1PR1HSP90AA1HSP90AB1SIRT2 | |
| SCHEMBL16303335 | 0.81 | CHRM2 (0.41) | CHRM2S1PR1HSP90AA1HSP90AB1SIRT2 | |
| SCHEMBL15637200 | 0.80 | KDM5B (0.58) | CHRM2S1PR1KDM5BKDM5AKDM5C | |
| SCHEMBL16292934 | 0.80 | CHRM2 (0.40) | CHRM2S1PR1HSP90AA1HSP90AB1SIRT2 | |
| SCHEMBL15994147 | 0.79 | CHRM2 (0.67) | CHRM2HSP90AA1HSP90AB1SIRT2CACNA2D1 | |
| SCHEMBL16292932 | 0.79 | S1PR1 (0.40) | CHRM2S1PR1HSP90AA1HSP90AB1SIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9221801-B2 | Inhibitors of histone demethylases | EPITHERAPEUTICS APS (DK) | 2015-12-29 | — | — | US | disclosed |
| US-20140371214-A1 | INHIBITORS OF HISTONE DEMETHYLASES | GILEAD SCIENCES, INC. | 2014-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371214-A1 | INHIBITORS OF HISTONE DEMETHYLASES | KDM1B, KDM1A, KDM3A | CHRM2 3004/4885S1PR1 3369/4885HSP90AA1 1609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.