Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16293497 | 1.00 | PIK3CD (0.61) | PIK3CDPIK3CBALOX12SMN1; SMN2PIK3CG | |
| SCHEMBL20067856 | 0.91 | PIK3CD (0.61) | PIK3CDPIK3CBALOX12SMN1; SMN2PIK3CG | |
| SCHEMBL15813106 | 0.88 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CGPIK3C3PIK3R1 | |
| SCHEMBL12885786 | 0.88 | PIK3CD (0.55) | PIK3CDPIK3CBPIK3CGPIK3C3PIK3R1 | |
| SCHEMBL22227598 | 0.86 | PIK3CD (0.51) | PIK3CDPIK3CBPIK3CGPIK3C3PIK3R1 | |
| SCHEMBL20061444 | 0.86 | PIK3CD (0.51) | PIK3CDPIK3CBPIK3CGPIK3C3PIK3R1 | |
| SCHEMBL28563990 | 0.85 | PIK3CD (0.55) | PIK3CDPIK3CBALOX12SMN1; SMN2PIK3CG | |
| SCHEMBL28563992 | 0.85 | PIK3CD (0.55) | PIK3CDPIK3CBALOX12SMN1; SMN2PIK3CG | |
| SCHEMBL2504520 | 0.84 | PIK3CD (0.59) | PIK3CDPIK3CBPIK3CGPIK3R1PIK3CA | |
| SCHEMBL12683042 | 0.84 | PIK3CD (0.59) | PIK3CDPIK3CBPIK3CGPIK3R1PIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107690433-B | Heteroaryl derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for preventing or treating PI3 kinase-associated diseases comprising the same as active ingredient | 韩国化学研究院 | 2021-04-09 | — | — | CN | disclosed |
| EP-3008053-B1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC (US) | 2018-03-21 | — | — | EP | disclosed |
| US-20160039793-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD SCIENCES, INC. | 2016-02-11 | — | — | US | disclosed |
| US-9221795-B2 | Phosphatidylinositol 3-kinase inhibitors | GILEAD SCIENCES, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20140371246-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC | 2014-12-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160039793-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, PIK3R4, PIK3R5 | PIK3CD 4/4885PIK3CB 11/4885ALOX12 4390/4885 |
| US-20140371246-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3CA, PIK3R4, PIK3R5 | PIK3CD 4/4885PIK3CB 11/4885ALOX12 4390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.