Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 5/20 | 0.72 |
| ▸ | AURKA | O14965 | 2/20 | 0.68 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.68 |
| ▸ | JAK2 | O60674 | 6/20 | 0.62 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.61 |
| ▸ | JAK3 | P52333 | 2/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.61 |
| ▸ | JAK1 | P23458 | 1/20 | 0.61 |
| ▸ | TYK2 | P29597 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.61 |
| ▸ | EGFR | P00533 | 2/20 | 0.61 |
| ▸ | IGF1R | P08069 | 3/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | PLK1 | P53350 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4387681 | 0.86 | JAK2 (0.77) | PLK4MAPK8JAK2JAK3HDAC3 | |
| SCHEMBL2565238 | 0.79 | HDAC8 (0.76) | HDAC8HDAC6TP53SMN1; SMN2MAPT | |
| SCHEMBL4377173 | 0.78 | JAK2 (0.77) | PLK4MAPK8JAK2JAK3HDAC3 | |
| SCHEMBL4384955 | 0.78 | JAK2 (0.77) | PLK4MAPK8JAK2JAK3HDAC3 | |
| SCHEMBL13321202 | 0.77 | EGFR (0.60) | AURKAMAPK8JAK2AURKBEGFR | |
| SCHEMBL13300660 | 0.77 | EGFR (0.73) | AURKAMAPK8AURKBEGFRIGF1R | |
| SCHEMBL4390255 | 0.77 | TP53 (0.72) | PLK4MAPK8JAK2JAK3HDAC3 | |
| SCHEMBL2880178 | 0.77 | JAK2 (0.72) | PLK4MAPK8JAK2JAK3HDAC3 | |
| SCHEMBL4393244 | 0.77 | JAK2 (0.78) | PLK4MAPK8JAK2JAK3HDAC3 | |
| SCHEMBL4378132 | 0.76 | JAK2 (0.77) | PLK4MAPK8JAK2JAK3HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3840752-A1 | PLATELET COUNT-AGNOSTIC METHODS OF TREATING MYELOFIBROSIS | Sierra Oncology, Inc. (US) | 2021-06-30 | — | — | EP | disclosed |
| WO-2020041466-A1 | PLATELET COUNT-AGNOSTIC METHODS OF TREATING MYELOFIBROSIS | SIERRA ONCOLOGY, INC. (US) | 2020-02-27 | — | — | WO | disclosed |
| WO-2014199166-A1 | METHOD OF INCREASING VIRAL GROWTH RATE AND/OR TITRE IN CELLS | UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS (GB) | 2014-12-18 | — | — | WO | disclosed |