Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 14/20 | 0.69 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.40 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16307607 | 0.88 | TTK (0.79) | TTKEGLN2 | |
| SCHEMBL16296112 | 0.87 | TTK (0.78) | TTKJAK2 | |
| SCHEMBL1932228 | 0.87 | TTK (0.82) | TTKPIK3CAPIK3CG | |
| SCHEMBL16295287 | 0.85 | TTK (0.79) | TTKJAK3 | |
| SCHEMBL15036897 | 0.84 | TTK (0.79) | TTK | |
| SCHEMBL16295250 | 0.83 | TTK (0.54) | TTK | |
| SCHEMBL16296295 | 0.83 | TTK (0.53) | TTK | |
| SCHEMBL16296221 | 0.82 | TTK (0.67) | TTK | |
| SCHEMBL1931869 | 0.81 | TTK (1.00) | TTKPIK3CAPIK3CG | |
| SCHEMBL16295859 | 0.81 | TTK (0.60) | TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3008061-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER | Bayer Pharma Aktiengesellschaft (DE) | 2016-04-20 | — | — | EP | disclosed |
| WO-2014198594-A1 | NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2014-12-18 | — | — | WO | disclosed |