Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.80 |
| ▸ | RAB9A | P51151 | 9/20 | 0.80 |
| ▸ | MEN1 | O00255 | 7/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.80 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.69 |
| ▸ | GFER | P55789 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | TP53 | P04637 | 3/20 | 0.63 |
| ▸ | CASP3 | P42574 | 1/20 | 0.63 |
| ▸ | CASP2 | P42575 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8771200 | 0.84 | NPC1 (0.89) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL19392293 | 0.84 | NPC1 (0.89) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL2063276 | 0.83 | NPC1 (0.86) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL1929165 | 0.82 | NPC1 (0.85) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL12495837 | 0.81 | NPC1 (1.00) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL7717513 | 0.81 | MEN1 (1.00) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL8770282 | 0.81 | MEN1 (0.85) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL27353966 | 0.81 | MEN1 (0.83) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL22804218 | 0.81 | NPC1 (0.83) | NPC1RAB9AMEN1KMT2ATDP1 | |
| SCHEMBL18993410 | 0.81 | NPC1 (0.83) | NPC1RAB9AMEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004060874-A1 | IMINO ACID DERIVATIVES FOR USE AS INHIBITORS OF MATRIX METALLOPROTEINASES | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2004-07-22 | — | — | WO | disclosed |