Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1486976 | 0.82 | PREP (0.43) | PREPNR1H2USP2SMN1; SMN2HPGD | |
| SCHEMBL22072991 | 0.82 | PREP (0.43) | PREPNR1H2USP2SMN1; SMN2HPGD | |
| SCHEMBL30242473 | 0.82 | PREP (0.43) | PREPNR1H2USP2SMN1; SMN2HPGD | |
| SCHEMBL30242510 | 0.82 | PREP (0.43) | PREPNR1H2USP2SMN1; SMN2HPGD | |
| SCHEMBL23971377 | 0.81 | PREP (0.43) | PREPNR1H2USP2SMN1; SMN2HPGD | |
| SCHEMBL18312409 | 0.81 | PREP (0.43) | PREPNR1H2USP2SMN1; SMN2HPGD | |
| SCHEMBL29744876 | 0.81 | PREP (0.43) | PREPNR1H2USP2SMN1; SMN2HPGD | |
| SCHEMBL17049887 | 0.79 | PREP (0.42) | PREPNR1H2USP2SMN1; SMN2HPGD | |
| SCHEMBL8182192 | 0.79 | PREP (0.42) | PREPNR1H2USP2SMN1; SMN2HPGD | |
| SCHEMBL18449799 | 0.77 | PREP (0.40) | PREPNR1H2USP2SMN1; SMN2HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021150697-A1 | N-SUBSTITUTED-3-TRICYCLYL PIPERIDINE DERIVATIVES AS ANTICANCER AND NEUROPROTECTIVE AGENTS | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2021-07-29 | — | — | WO | disclosed |
| WO-2012054535-A2 | COMPOUNDS, COMPOSITIONS AND METHODS USEFUL FOR CHOLESTEROL MOBILISATION | CERENIS THERAPEUTICS SA (FR) | 2012-04-26 | — | — | WO | disclosed |