Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 11/20 | 0.57 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.49 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | BMX | P51813 | 2/20 | 0.41 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16250301 | 0.93 | ABCB1 (0.51) | SMOABCB1ABCC1MEN1KMT2A | |
| SCHEMBL8219239 | 0.92 | SMO (0.68) | SMOABCB1ABCC1MAPK14MEN1 | |
| SCHEMBL16250300 | 0.90 | SMO (0.68) | SMOABCB1ABCC1MAPK14KDM4E | |
| SCHEMBL12964928 | 0.88 | SMO (0.62) | SMOABCB1ABCC1MAPK14MEN1 | |
| SCHEMBL16250298 | 0.84 | SMO (0.58) | SMOABCB1ABCC1MEN1KMT2A | |
| SCHEMBL11911340 | 0.83 | SMO (0.71) | SMOABCB1MAPK14RAB9AALDH1A1 | |
| SCHEMBL8225752 | 0.83 | SMO (0.82) | SMOABCB1MAPK14 | |
| SCHEMBL8222702 | 0.82 | SMO (0.80) | SMOABCB1ABCC1MAPK14KMT2A | |
| SCHEMBL8223132 | 0.81 | SMO (0.79) | SMOABCB1MAPK14MEN1KMT2A | |
| SCHEMBL15492187 | 0.79 | SMO (0.76) | SMOABCB1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120196865-A1 | Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway | UNIVERSITE DE STRASBOURG (FR) | 2012-08-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120196865-A1 | Acyl Guanidine Derivatives Modulating The Hedgehog Protein Signaling Pathway | SHH, GLI1, SMO | SMO 3/4885ABCB1 3465/4885ABCC1 1842/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.