Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16290631 | 0.82 | TSHR (0.43) | TSHRMAPTNPC1SMN1; SMN2MEN1 | |
| SCHEMBL16290972 | 0.78 | FYN (0.41) | TSHRMAPTNPC1SMN1; SMN2MEN1 | |
| SCHEMBL16303540 | 0.76 | TSHR (0.43) | TSHRMAPTNPC1SMN1; SMN2MEN1 | |
| SCHEMBL16311812 | 0.75 | MAPK10 (0.44) | TSHRMAPTMEN1KMT2AFYN | |
| SCHEMBL3790825 | 0.73 | CTSA (0.44) | TSHRMAPTNPC1SMN1; SMN2MEN1 | |
| SCHEMBL16290889 | 0.70 | CYP1A1 (0.56) | KMT2ACYP1A1CYP1A2CYP1B1NOTUM | |
| SCHEMBL8066084 | 0.69 | PDE4B (0.51) | TSHRMAPTNPC1SMN1; SMN2MEN1 | |
| SCHEMBL6315146 | 0.69 | PDE4B (0.46) | TSHRMAPTNPC1SMN1; SMN2MEN1 | |
| SCHEMBL16290880 | 0.69 | MAPK10 (0.44) | TSHRMAPTNPC1SMN1; SMN2FYN | |
| SCHEMBL12999936 | 0.68 | ESR2 (0.58) | TP53ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014201206-A1 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. (US) | 2014-12-18 | — | — | WO | disclosed |
| WO-2014201173-A1 | BICYCLIC SULFONAMIDE COMPOUNDS AS SODIUM CHANNEL INHIBITORS | AMGEN INC. (US) | 2014-12-18 | — | — | WO | disclosed |