SCHEMBL16307352

SCHEMBL16307352

Brc1ccc(N(c2cccc(-c3ccccn3)c2)c2cccc(-c3ccccn3)c2)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 4/20 0.43
CYP2A6 P11509 1/20 0.40
HTR1A P08908 1/20 0.40
HTR7 P34969 1/20 0.40
TLR4 O00206 1/20 0.39
TLR2 O60603 1/20 0.39
KDM4E B2RXH2 2/20 0.38
LMNA P02545 2/20 0.38
CCR1 P32246 2/20 0.38
CCR5 P51681 2/20 0.38
CCR8 P51685 2/20 0.38
CYP1A2 P05177 1/20 0.38
POLB P06746 1/20 0.38
METAP1 P53582 1/20 0.38
BLM P54132 1/20 0.38
HIF1A Q16665 1/20 0.38
DOHH Q9BU89 1/20 0.38
P4HTM Q9NXG6 1/20 0.38
HRH3 Q9Y5N1 1/20 0.38
TP53 P04637 3/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26849314 0.92 CYP2A6 (0.46) CYP2A6HTR1AHTR7TLR4TLR2
SCHEMBL5102763 0.91 CYP2A6 (0.44) GRM5CYP2A6HTR1AHTR7TLR4
SCHEMBL15133747 0.89 GRM5 (0.50) GRM5CYP2A6HTR1AHTR7TLR4
SCHEMBL30109153 0.89 CYP2A6 (0.46) CYP2A6HTR1AHTR7TLR4TLR2
SCHEMBL5115970 0.89 CYP2A6 (0.46) CYP2A6HTR1AHTR7TLR4TLR2
SCHEMBL16484524 0.89 CYP2A6 (0.46) CYP2A6HTR1AHTR7TLR4TLR2
SCHEMBL15133751 0.85 CYP2A6 (0.40) CYP2A6HTR1AHTR7TLR4TLR2
SCHEMBL15606465 0.82 CYP2A6 (0.40) GRM5CYP2A6HTR1AHTR7TLR4
SCHEMBL28432843 0.81 GRM5 (0.43) GRM5CYP2A6HTR1AHTR7TLR4
SCHEMBL3141411 0.80 CYP2A6 (0.41) GRM5CYP2A6HTR1AHTR7TLR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170317298-A1 ORGANIC METAL COMPLEXES UDC IRELAND LIMITED (IE) 2017-11-02 US disclosed
US-20170317298-A1 ORGANIC METAL COMPLEXES UDC IRELAND LIMITED (IE) 2017-11-02 US disclosed
US-9748502-B2 Organic metal complexes MERCK PATENT GMBH (DE) 2017-08-29 US disclosed
US-9748502-B2 Organic metal complexes MERCK PATENT GMBH (DE) 2017-08-29 US disclosed
US-20140371825-A1 ORGANIC METAL COMPLEXES UDC IRELAND LIMITED (IE) 2014-12-18 US disclosed
US-20140371825-A1 ORGANIC METAL COMPLEXES UDC IRELAND LIMITED (IE) 2014-12-18 US disclosed