Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 16/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.37 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16308052 | 1.00 | PIK3CB (0.41) | PIK3CBPDCD1CD274PIK3CDPIK3CA | |
| SCHEMBL16308053 | 0.87 | PIK3CB (0.44) | PIK3CBPDCD1CD274PIK3CDPIK3CA | |
| SCHEMBL15029848 | 0.85 | PIK3CB (0.42) | PIK3CBPDCD1CD274PIK3CDPIK3CA | |
| SCHEMBL15029283 | 0.85 | PIK3CB (0.41) | PIK3CBPDCD1CD274PIK3CDPIK3CA | |
| SCHEMBL15029320 | 0.85 | PIK3CB (0.41) | PIK3CBPDCD1CD274PIK3CDPIK3CA | |
| SCHEMBL15029284 | 0.84 | PIK3CB (0.40) | PIK3CBPDCD1CD274PIK3CDPIK3CA | |
| SCHEMBL16308054 | 0.84 | PIK3CB (0.40) | PIK3CBPDCD1CD274PIK3CDPIK3CA | |
| SCHEMBL15029611 | 0.82 | PIK3CB (0.63) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL15029615 | 0.82 | PIK3CB (0.63) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL15029589 | 0.79 | PIK3CB (0.40) | PIK3CBPDCD1CD274PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |