Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 17/20 | 0.73 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.64 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.64 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.64 |
| ▸ | MTOR | P42345 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10124435 | 0.97 | PIK3CB (0.69) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL15029372 | 0.88 | PIK3CB (0.85) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL10124418 | 0.88 | PIK3CB (0.73) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL15009649 | 0.87 | PIK3CB (0.80) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL15029953 | 0.86 | PIK3CB (0.82) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL10124437 | 0.86 | PIK3CB (0.70) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL9949421 | 0.85 | PIK3CB (0.80) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL15029974 | 0.85 | PIK3CB (0.80) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL9949857 | 0.85 | PIK3CB (0.80) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL9949850 | 0.85 | PIK3CB (0.80) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604601-B1 | HETERO RING COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-02-24 | — | — | EP | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |