Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CB | P42338 | 19/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 12/20 | 0.52 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.49 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.47 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15029482 | 0.96 | PIK3CB (0.54) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL17529172 | 0.94 | PIK3CB (0.53) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL16308474 | 0.93 | PIK3CB (0.53) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3R1 | |
| SCHEMBL15009375 | 0.92 | PIK3CB (0.58) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL16308376 | 0.92 | PIK3CB (0.58) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL17529041 | 0.91 | PIK3CB (0.68) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL15030035 | 0.91 | PIK3CB (0.56) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL16308386 | 0.90 | PIK3CB (0.53) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL15030038 | 0.90 | PIK3CB (0.56) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B | |
| SCHEMBL16308381 | 0.90 | PIK3CB (0.55) | PIK3CBPIK3CDPIK3CAPIK3CGPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2604601-B1 | HETERO RING COMPOUND | ASTELLAS PHARMA INC (JP) | 2016-02-24 | — | — | EP | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |
| US-8912180-B2 | Heterocyclic compound | ASTELLAS PHARMA INC. (JP) | 2014-12-16 | — | — | US | disclosed |