Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK1 | Q13153 | 6/20 | 0.80 |
| ▸ | PKN1 | Q16512 | 4/20 | 0.80 |
| ▸ | PAK4 | O96013 | 3/20 | 0.80 |
| ▸ | WEE1 | P30291 | 1/20 | 0.71 |
| ▸ | PAK2 | Q13177 | 4/20 | 0.70 |
| ▸ | PAK3 | O75914 | 3/20 | 0.70 |
| ▸ | CDK4 | P11802 | 3/20 | 0.58 |
| ▸ | CCND1 | P24385 | 3/20 | 0.58 |
| ▸ | CCND2 | P30279 | 3/20 | 0.58 |
| ▸ | CCND3 | P30281 | 3/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.57 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.57 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.57 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.57 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.55 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 2/20 | 0.51 |
| ▸ | TNK2 | Q07912 | 4/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15035989 | 1.00 | PAK1 (0.80) | PAK1PKN1PAK4WEE1PAK2 | |
| SCHEMBL15281586 | 0.94 | PAK1 (0.72) | PAK1PKN1PAK4WEE1PAK2 | |
| SCHEMBL15035966 | 0.92 | PAK1 (0.67) | PAK1PKN1PAK4WEE1PAK2 | |
| SCHEMBL16309172 | 0.92 | PAK1 (0.67) | PAK1PKN1PAK4WEE1PAK2 | |
| SCHEMBL15035988 | 0.91 | PAK1 (0.75) | PAK1PKN1PAK4WEE1PAK2 | |
| SCHEMBL15035990 | 0.91 | PAK1 (0.66) | PAK1PKN1PAK4WEE1PAK2 | |
| SCHEMBL15035985 | 0.90 | PAK1 (0.74) | PAK1PKN1PAK4WEE1PAK2 | |
| SCHEMBL15281631 | 0.89 | PAK1 (0.68) | PAK1PKN1PAK4WEE1PAK2 | |
| SCHEMBL15030376 | 0.89 | WEE1 (0.68) | PAK1PKN1PAK4WEE1PAK2 | |
| SCHEMBL15035978 | 0.89 | PAK1 (0.63) | PAK1PKN1PAK4WEE1PAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |