Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | PAK3 | O75914 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.40 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.40 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.40 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.40 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.39 |
| ▸ | TNK2 | Q07912 | 7/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | CDK4 | P11802 | 2/20 | 0.37 |
| ▸ | CCND1 | P24385 | 2/20 | 0.37 |
| ▸ | CCND2 | P30279 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16310840 | 0.92 | FGFR1 (0.43) | FGFR1FGFR4KDRPAK3PAK4 | |
| SCHEMBL15036001 | 0.92 | FGFR1 (0.43) | FGFR1FGFR4KDRPAK3PAK4 | |
| SCHEMBL15281052 | 0.92 | FGFR1 (0.43) | FGFR1FGFR4KDRPAK3PAK4 | |
| SCHEMBL14681974 | 0.80 | FGFR1 (0.45) | FGFR1FGFR4KDRPAK3PAK4 | |
| SCHEMBL16309188 | 0.77 | TNK2 (0.48) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15036103 | 0.76 | PAK3 (0.54) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15041867 | 0.73 | FGFR1 (0.47) | FGFR1FGFR4KDRPAK3PAK4 | |
| SCHEMBL15035693 | 0.72 | TNK2 (0.47) | FGFR1FGFR4KDRPAK3PAK4 | |
| SCHEMBL15036096 | 0.71 | FGFR1 (0.45) | FGFR1FGFR4KDRPAK3PAK4 | |
| SCHEMBL15036081 | 0.71 | WEE1 (0.45) | FGFR1FGFR4KDRPAK3PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |