Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAK3 | O75914 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.46 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.46 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.46 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.46 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 14/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCND2 | P30279 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | WEE1 | P30291 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15036044 | 0.93 | PAK3 (0.45) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15041663 | 0.86 | PAK3 (0.45) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL16309190 | 0.84 | PAK3 (0.53) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL16511952 | 0.78 | PAK3 (0.57) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15041690 | 0.78 | PAK1 (0.52) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL15036082 | 0.77 | PAK3 (0.51) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL16309179 | 0.74 | TNK2 (0.52) | PAK3PAK4LIMK1LIMK2PAK1 | |
| SCHEMBL16309198 | 0.74 | WEE1 (0.52) | PAK3PAK4PAK1PAK2PKN1 | |
| SCHEMBL16570446 | 0.73 | JAK2 (0.49) | WEE1KCNH2 | |
| SCHEMBL15041367 | 0.72 | PAK3 (0.54) | PAK3PAK4LIMK1LIMK2PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |