Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 19/20 | 0.48 |
| ▸ | PAK3 | O75914 | 1/20 | 0.42 |
| ▸ | PAK4 | O96013 | 1/20 | 0.42 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.42 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.42 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.42 |
| ▸ | PAK2 | Q13177 | 1/20 | 0.42 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15036060 | 0.96 | TNK2 (0.48) | TNK2PAK3PAK4LIMK1LIMK2 | |
| SCHEMBL15036138 | 0.87 | TNK2 (0.48) | TNK2PAK3PAK4LIMK1LIMK2 | |
| SCHEMBL16309177 | 0.77 | PTK2 (0.43) | TNK2PAK4PKN1 | |
| SCHEMBL15036015 | 0.76 | PTK2 (0.48) | TNK2PAK4PKN1 | |
| SCHEMBL13553749 | 0.76 | TNK2 (0.53) | TNK2PAK3PAK4LIMK1LIMK2 | |
| SCHEMBL15036388 | 0.74 | TNK2 (0.42) | TNK2PAK3PAK4LIMK1LIMK2 | |
| SCHEMBL15036034 | 0.74 | TNK2 (0.55) | TNK2PAK3PAK4LIMK1LIMK2 | |
| SCHEMBL15785302 | 0.74 | TNK2 (0.51) | TNK2PAK3PAK4LIMK1LIMK2 | |
| SCHEMBL16310846 | 0.73 | WEE1 (0.40) | TNK2 | |
| SCHEMBL15034870 | 0.73 | PAK4 (0.53) | TNK2PAK3PAK4LIMK1LIMK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |