Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | BRD4 | O60885 | 5/20 | 0.49 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | BRD2 | P25440 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.49 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.49 |
| ▸ | CDK4 | P11802 | 12/20 | 0.48 |
| ▸ | CCND1 | P24385 | 12/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.48 |
| ▸ | CDK2 | P24941 | 8/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 6/20 | 0.48 |
| ▸ | FGFR4 | P22455 | 6/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.48 |
| ▸ | WEE1 | P30291 | 2/20 | 0.47 |
| ▸ | CCND2 | P30279 | 5/20 | 0.46 |
| ▸ | CCND3 | P30281 | 5/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15036092 | 0.91 | BRD4 (0.48) | JAK2BRD4JAK1BRD2JAK3 | |
| SCHEMBL15035787 | 0.82 | CDK4 (0.48) | JAK2BRD4JAK1BRD2JAK3 | |
| SCHEMBL16309179 | 0.81 | TNK2 (0.52) | WEE1PAK4PAK1PKN1 | |
| SCHEMBL15034780 | 0.80 | CDK4 (0.49) | JAK2BRD4CDK4CCND1CCNA2 | |
| SCHEMBL15237036 | 0.79 | CDK4 (0.52) | JAK2BRD4CDK4CCND1CCNA2 | |
| SCHEMBL15236997 | 0.79 | CDK4 (0.48) | CDK4CCND1CCNA2CDK2FGFR1 | |
| SCHEMBL15035980 | 0.78 | PAK1 (0.64) | CDK4CCNA2CDK2FGFR1FGFR2 | |
| SCHEMBL15041871 | 0.78 | WEE1 (0.71) | CDK4CCND1CCNA2CDK2FGFR1 | |
| SCHEMBL15035609 | 0.77 | PAK3 (0.66) | JAK2BRD4JAK1BRD2JAK3 | |
| SCHEMBL15030375 | 0.77 | WEE1 (0.71) | JAK2JAK3CDK4CCND1FGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |