Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | JAK2 | O60674 | 2/20 | 0.44 |
| ▸ | PAK4 | O96013 | 1/20 | 0.44 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.44 |
| ▸ | CDK4 | P11802 | 1/20 | 0.42 |
| ▸ | CCND1 | P24385 | 1/20 | 0.42 |
| ▸ | CCND2 | P30279 | 1/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.42 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.41 |
| ▸ | WEE1 | P30291 | 5/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.40 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.39 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15036135 | 0.90 | WEE1 (0.43) | BRD4JAK2PAK4PKN1CDK4 | |
| SCHEMBL15785310 | 0.86 | PAK4 (0.44) | BRD4JAK2PAK4PKN1CDK4 | |
| SCHEMBL13553909 | 0.83 | PKN1 (0.56) | BRD4JAK2PAK4PKN1CDK4 | |
| SCHEMBL14682014 | 0.79 | JAK2 (0.49) | BRD4JAK2PAK4PKN1CDK4 | |
| SCHEMBL15041487 | 0.79 | CDK4 (0.61) | JAK2PAK4PKN1CDK4CCND1 | |
| SCHEMBL16309182 | 0.79 | PAK4 (0.48) | PAK4PKN1TNK2 | |
| SCHEMBL16309186 | 0.78 | BRD4 (0.53) | BRD4JAK2PAK4PKN1CDK4 | |
| SCHEMBL15036459 | 0.76 | CDK4 (0.48) | BRD4JAK2PAK4PKN1CDK4 | |
| SCHEMBL15036071 | 0.76 | BRD4 (0.52) | BRD4JAK2PAK4PKN1CDK4 | |
| SCHEMBL15041453 | 0.76 | BRD4 (0.52) | BRD4JAK2PAK4PKN1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8912203-B2 | 6-(sulfonylaryl)pyrido[2,3-D]pyrimidin-7(8H)-ones for the treatment of CNS disorders | AFRAXIS HOLDINGS, INC. (US) | 2014-12-16 | — | — | US | disclosed |