Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 17/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16309582 | 0.93 | GRM5 (0.68) | GRM5 | |
| SCHEMBL16309589 | 0.92 | GRM5 (0.57) | GRM5 | |
| SCHEMBL16309593 | 0.92 | GRM5 (0.62) | GRM5KDM4EALDH1A1LMNAHTT | |
| SCHEMBL16309542 | 0.92 | GRM5 (0.67) | GRM5KDM4E | |
| SCHEMBL16704510 | 0.90 | GRM5 (0.55) | GRM5 | |
| SCHEMBL16309547 | 0.89 | GRM5 (0.70) | GRM5KDM4EALDH1A1HTT | |
| SCHEMBL16309523 | 0.89 | GRM5 (0.59) | GRM5 | |
| SCHEMBL16704519 | 0.89 | GRM5 (0.59) | GRM5 | |
| SCHEMBL16309551 | 0.88 | GRM5 (0.64) | GRM5 | |
| SCHEMBL16309474 | 0.88 | GRM5 (0.64) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150216863-A1 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | UNIV VANDERBILT (US) | 2015-08-06 | — | — | US | disclosed |
| US-20150216863-A1 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | UNIV VANDERBILT (US) | 2015-08-06 | — | — | US | disclosed |
| US-9029366-B2 | Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2015-05-12 | — | — | US | disclosed |
| US-9029366-B2 | Substituted bicyclic alkoxy pyrazole analogs as allosteric modulators of mGluR5 receptors | VANDERBILT UNIVERSITY (US) | 2015-05-12 | — | — | US | disclosed |
| WO-2013192346-A9 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | VANDERBILT UNIVERSITY (US) | 2014-12-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150216863-A1 | SUBSTITUTED BICYCLIC ALKOXY PYRAZOLE ANALOGS AS ALLOSTERIC MODULATORS OF MGLUR5 RECEPTORS | GRM5, GRIK5, GRM3 | GRM5 1/4885KDM4E 1440/4885ALDH1A1 4319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.