Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 9/20 | 0.51 |
| ▸ | CDK6 | Q00534 | 9/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.51 |
| ▸ | CCND3 | P30281 | 8/20 | 0.51 |
| ▸ | CCNK | O75909 | 1/20 | 0.51 |
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CDK4 | P11802 | 18/20 | 0.48 |
| ▸ | CCND1 | P24385 | 15/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.46 |
| ▸ | CCND2 | P30279 | 4/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1642972 | 0.92 | CDK6 (0.49) | CDK2CDK6CCNA2CCND3CCNK | |
| SCHEMBL1115373 | 0.88 | CDK4 (0.48) | CDK2CDK6CCNA2CCND3CCNK | |
| SCHEMBL1643395 | 0.88 | CDK4 (0.46) | CDK2CDK6CCNA2CCND3CCNK | |
| SCHEMBL1643493 | 0.86 | CDK4 (0.51) | CDK2CDK6CCNA2CCND3CCNK | |
| SCHEMBL1115483 | 0.85 | CDK4 (0.52) | CDK2CDK6CCNA2CCND3CCNK | |
| SCHEMBL2564026 | 0.84 | CDK4 (0.53) | CDK2CDK6CCNA2CCND3CDK4 | |
| SCHEMBL1115328 | 0.82 | WEE1 (0.52) | CDK2CDK6CCNA2CCND3CDK4 | |
| SCHEMBL1115188 | 0.78 | CDK6 (0.51) | CDK2CDK6CCNA2CCND3CCNK | |
| SCHEMBL1115336 | 0.78 | CDK4 (0.50) | CDK2CDK6CCNA2CCND3CCNK | |
| SCHEMBL16359416 | 0.77 | CDK4 (0.47) | CDK2CDK6CCNA2CCND3CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2278973-B1 | GEM-DISUBSTITUTED AND SPIROCYCLIC AMINO PYRIDINES/PYRIMIDINES AS CELL CYCLE INHIBITORS | AMGEN INC (US) | 2011-11-02 | — | — | EP | disclosed |