SCHEMBL16319229

SCHEMBL16319229

COc1ccc(F)c(-c2ccc(O)cc2C(F)CC(C)(C)C)c1

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 15/20 0.40
ALDH1A1 P00352 1/20 0.37
GAA P10253 1/20 0.37
USP7 Q93009 1/20 0.36
GRIN1 Q05586 1/20 0.36
GRIN2B Q13224 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16318953 0.84 FFAR1 (0.47) FFAR1
SCHEMBL16318863 0.84 FFAR1 (0.38) FFAR1ALDH1A1GAA
SCHEMBL16318618 0.82 FFAR1 (0.45) FFAR1USP7
SCHEMBL16318775 0.81 FFAR1 (0.43) FFAR1ALDH1A1GAA
SCHEMBL16318717 0.80 FFAR1 (0.46) FFAR1USP7
SCHEMBL16318590 0.77 FFAR1 (0.48) FFAR1ALDH1A1GAA
SCHEMBL16318931 0.75 NPC1 (0.45) ALDH1A1GAA
SCHEMBL16318940 0.75 FFAR1 (0.41) FFAR1
SCHEMBL16319171 0.74 FFAR1 (0.41) FFAR1USP7
SCHEMBL16318998 0.74 FFAR1 (0.39) FFAR1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9382188-B2 Aromatic ring compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2016-07-05 US disclosed
EP-2816023-A1 AROMATIC RING COMPOUND Takeda Pharmaceutical Company Limited (JP) 2014-12-24 EP disclosed