Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.59 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.49 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319214 | 0.87 | SCN9A (0.62) | SCN9ASCN5AFLT1FLT4KDR | |
| SCHEMBL16319524 | 0.86 | SCN9A (0.53) | SCN9ASCN5AFLT1FLT4KDR | |
| SCHEMBL16319522 | 0.85 | SCN9A (0.60) | SCN9ASCN5A | |
| SCHEMBL16319362 | 0.84 | SCN9A (0.53) | SCN9ASCN5A | |
| SCHEMBL678843 | 0.84 | FLT1 (0.60) | SCN9AFLT1FLT4KDR | |
| SCHEMBL16319794 | 0.82 | SCN9A (0.73) | SCN9ASCN5A | |
| SCHEMBL679799 | 0.81 | SCN9A (0.48) | SCN9ASCN5A | |
| SCHEMBL679718 | 0.81 | SCN9A (0.56) | SCN9AFLT1FLT4KDR | |
| SCHEMBL16319923 | 0.79 | FLT1 (0.59) | SCN9AFLT1FLT4KDR | |
| SCHEMBL365203 | 0.78 | SCN9A (0.60) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |