Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 3/20 | 0.48 |
| ▸ | TBXA2R | P21731 | 4/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.44 |
| ▸ | HTR2A | P28223 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29255047 | 0.81 | AR (0.48) | ARTBXA2RKCNH2SLC6A4HTR2A | |
| SCHEMBL366867 | 0.81 | FFAR1 (0.50) | ARTBXA2RKCNH2SLC6A4HTR2A | |
| SCHEMBL20554635 | 0.81 | TBXA2R (0.50) | ARTBXA2RKCNH2SLC6A4HTR2A | |
| SCHEMBL20554608 | 0.79 | AR (0.75) | ARTBXA2RKCNH2SLC6A4HTR2A | |
| SCHEMBL11649803 | 0.77 | SLC6A4 (0.57) | ARTBXA2RKCNH2SLC6A4HTR2A | |
| SCHEMBL2259191 | 0.77 | MAOB (0.57) | ARKDM4EMEN1MAPTKMT2A | |
| SCHEMBL28084858 | 0.75 | MAOB (0.55) | ARKDM4EMEN1MAPTKMT2A | |
| SCHEMBL26835414 | 0.75 | AR (0.43) | ARTBXA2RKCNH2SLC6A4HTR2A | |
| SCHEMBL2964216 | 0.74 | MAPT (0.70) | ARTBXA2RKCNH2SLC6A4HTR2A | |
| SCHEMBL13343061 | 0.74 | FFAR1 (0.47) | ARTBXA2RKCNH2SLC6A4HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |