Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | CTSA | P10619 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.35 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 4/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632815 | 0.92 | MAPT (0.39) | MAPTKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL1632188 | 0.92 | MAPT (0.39) | MAPTKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL1632116 | 0.92 | MEN1 (0.41) | MAPTKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL1630459 | 0.92 | MEN1 (0.41) | MAPTKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL1631426 | 0.91 | MAPT (0.38) | MAPTKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL1632287 | 0.90 | MAPT (0.39) | MAPTKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL1632426 | 0.90 | MAPT (0.39) | MAPTKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL1629822 | 0.89 | MAPT (0.39) | MAPTKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL1632369 | 0.89 | MAPT (0.39) | MAPTKDM4EMEN1KMT2AL3MBTL1 | |
| SCHEMBL1632910 | 0.89 | KDM4E (0.40) | MAPTKDM4EMEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932270-B2 | Certain chemical entities, compositions, and methods | CYTOKINETICS, INC. (US) | 2011-04-26 | — | — | US | disclosed |