SCHEMBL16319586

SCHEMBL16319586

Cc1cc(C#N)cc(C)c1Oc1cc(F)c(C(=O)NS(C)(=O)=O)cc1F

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SCN9A Q15858 20/20 0.54
SCN5A Q14524 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL703173 0.83 SCN9A (0.61) SCN9ASCN5A
SCHEMBL679781 0.83 SCN9A (0.67) SCN9ASCN5A
SCHEMBL16319323 0.82 SCN9A (0.65) SCN9ASCN5A
SCHEMBL678800 0.80 SCN9A (0.63) SCN9ASCN5A
SCHEMBL680341 0.79 SCN9A (0.61) SCN9ASCN5A
SCHEMBL16319775 0.79 SCN9A (0.53) SCN9ASCN5A
SCHEMBL16319559 0.79 SCN9A (0.53) SCN9ASCN5A
SCHEMBL1690179 0.78 SCN9A (0.53) SCN9ASCN5A
SCHEMBL1690183 0.78 SCN9A (0.53) SCN9ASCN5A
SCHEMBL680335 0.78 SCN9A (0.63) SCN9ASCN5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2593427-B1 SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN PFIZER LTD (GB) 2014-12-24 EP disclosed