Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.57 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 3/20 | 0.51 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.50 |
| ▸ | ARAF | P10398 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16319791 | 0.88 | BRAF (0.52) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL16319405 | 0.87 | BRAF (0.51) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL364213 | 0.85 | CHEK2 (0.64) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL16319316 | 0.82 | PPARG (0.49) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL16320136 | 0.81 | SCN9A (0.61) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL16319795 | 0.81 | SCN9A (0.55) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL364276 | 0.80 | SCN9A (0.54) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL16319516 | 0.79 | SCN9A (0.48) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL16319732 | 0.79 | SCN9A (0.48) | BRAFHDAC1HDAC3HDAC4HDAC7 | |
| SCHEMBL5460005 | 0.78 | MAPK10 (0.53) | MAPK8MAPK10CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |