Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 16/20 | 0.57 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.57 |
| ▸ | FLT1 | P17948 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.45 |
| ▸ | RAF1 | P04049 | 2/20 | 0.45 |
| ▸ | BRAF | P15056 | 2/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.45 |
| ▸ | ARAF | P10398 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680222 | 0.91 | SCN9A (0.63) | SCN9ASCN5A | |
| SCHEMBL365203 | 0.90 | SCN9A (0.60) | SCN9ASCN5A | |
| SCHEMBL371116 | 0.87 | SCN9A (0.67) | SCN9ASCN5AKDRHDAC3RAF1 | |
| SCHEMBL16319584 | 0.85 | SCN9A (0.60) | SCN9ASCN5A | |
| SCHEMBL16319431 | 0.85 | SCN9A (0.68) | SCN9ASCN5A | |
| SCHEMBL680188 | 0.85 | SCN9A (0.59) | SCN9ASCN5A | |
| SCHEMBL16319523 | 0.84 | SCN9A (0.56) | SCN9ASCN5AFLT1FLT4KDR | |
| SCHEMBL16319537 | 0.83 | SCN9A (0.78) | SCN9ASCN5A | |
| SCHEMBL369786 | 0.83 | SCN9A (0.81) | SCN9ASCN5A | |
| SCHEMBL16319564 | 0.82 | SCN9A (0.56) | SCN9ASCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593427-B1 | SULFONAMIDE DERIVATIVES AS NAV1.7 INHIBITORS FOR THE TREATMENT OF PAIN | PFIZER LTD (GB) | 2014-12-24 | — | — | EP | disclosed |