Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | AOC1 | P19801 | 3/20 | 0.37 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 3/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | KMT5B | Q4FZB7 | 1/20 | 0.32 |
| ▸ | KMT5C | Q86Y97 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2374957 | 0.76 | NPSR1 (0.42) | KDM4EGAAMAPTLMNAMEN1 | |
| SCHEMBL3409550 | 0.72 | KDM4E (0.58) | KDM4EGAAMAPTIDO1AOC1 | |
| SCHEMBL7048199 | 0.71 | KMT2A (0.57) | KDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL27082221 | 0.70 | IDO1 (0.46) | KDM4EGAAMAPTIDO1PTGS1 | |
| SCHEMBL11657181 | 0.70 | MAPT (0.47) | KDM4EGAAMAPTIDO1AOC1 | |
| SCHEMBL3919638 | 0.70 | MAPT (0.47) | KDM4EGAAMAPTIDO1AOC1 | |
| SCHEMBL28188825 | 0.70 | MAPT (0.47) | KDM4EGAAMAPTIDO1AOC1 | |
| SCHEMBL14660988 | 0.69 | KMT5B (0.34) | KDM4EGAAMAPTAOC1KMT2A | |
| SCHEMBL28455999 | 0.68 | KDM4E (0.41) | KDM4EGAAMAPTIDO1LMNA | |
| SCHEMBL2183671 | 0.67 | MAPT (0.48) | KDM4EGAAMAPTIDO1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2544684-B1 | 4,4-DISUBSTITUTED PIPERIDINE DERIVATIVES USEFUL AS INHIBITORS OF DIPEPTIDYL PEPTIDASE-1 (DPP-1) | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-24 | — | — | EP | disclosed |