Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.60 |
| ▸ | JAK1 | P23458 | 5/20 | 0.60 |
| ▸ | TYK2 | P29597 | 5/20 | 0.60 |
| ▸ | JAK3 | P52333 | 5/20 | 0.60 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.51 |
| ▸ | BRD4 | O60885 | 5/20 | 0.46 |
| ▸ | SYK | P43405 | 2/20 | 0.43 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.43 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632625 | 0.91 | JAK2 (0.62) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL13498292 | 0.88 | JAK3 (0.63) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633307 | 0.88 | JAK2 (0.61) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633012 | 0.85 | JAK2 (0.57) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1631338 | 0.83 | JAK2 (0.57) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1635098 | 0.82 | JAK2 (0.74) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633259 | 0.82 | JAK2 (0.63) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633493 | 0.82 | JAK2 (0.58) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1634109 | 0.82 | JAK2 (0.67) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633545 | 0.80 | JAK2 (0.65) | JAK2JAK1TYK2JAK3TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |