Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMPR2 | Q13873 | 6/20 | 0.52 |
| ▸ | CDK2 | P24941 | 14/20 | 0.52 |
| ▸ | CDK1 | P06493 | 13/20 | 0.52 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 10/20 | 0.52 |
| ▸ | CDK9 | P50750 | 10/20 | 0.52 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.52 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.52 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.52 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | CCND3 | P30281 | 1/20 | 0.52 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.52 |
| ▸ | AURKA | O14965 | 3/20 | 0.51 |
| ▸ | DCLK1 | O15075 | 3/20 | 0.51 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.51 |
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634282 | 0.90 | ACVR1 (0.52) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL1632814 | 0.89 | CDK2 (0.52) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL1633703 | 0.85 | AURKA (0.48) | BMPR2CDK2CDK1CCNT1CCNB1 | |
| SCHEMBL1633395 | 0.81 | CDK2 (0.49) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL1632161 | 0.80 | CDK1 (0.59) | BMPR2CDK2CDK1CCNT1CCNB1 | |
| SCHEMBL1632891 | 0.79 | JAK2 (0.48) | CDK2CDK1CCNB1CDK9CCNA2 | |
| SCHEMBL1631342 | 0.79 | CDK2 (0.45) | CDK2CDK1CCNT1CCNB1CDK9 | |
| SCHEMBL1634895 | 0.78 | CA1 (0.51) | CDK2CDK5CDK5R1 | |
| SCHEMBL1636291 | 0.78 | JAK3 (0.56) | BMPR2CDK2CDK1CCNT1CCNB1 | |
| SCHEMBL13498292 | 0.78 | JAK3 (0.63) | BMPR2CDK2CDK1CCNT1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |