Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 9/20 | 0.77 |
| ▸ | RANBP1 | P43487 | 1/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.77 |
| ▸ | ESR1 | P03372 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | F7 | P08709 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.36 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16323808 | 1.00 | XPO1 (0.77) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL16361442 | 1.00 | XPO1 (0.77) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL17788715 | 0.93 | XPO1 (0.68) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL20230463 | 0.93 | XPO1 (0.68) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL17788714 | 0.93 | XPO1 (0.68) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL17790526 | 0.92 | XPO1 (0.66) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL29595559 | 0.91 | XPO1 (0.63) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL16324580 | 0.91 | XPO1 (0.63) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL16361443 | 0.91 | XPO1 (0.63) | XPO1RANBP1KCNH2ESR1HTR1A | |
| SCHEMBL16324581 | 0.91 | XPO1 (0.63) | XPO1RANBP1KCNH2ESR1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12577225-B2 | Nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2026-03-17 | — | — | US | disclosed |
| US-20250059158-A1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | WILMINGTON SAVINGS FUND SOCIETY, FSB, AS AGENT | 2025-02-20 | — | — | US | disclosed |
| US-11945794-B2 | Nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2024-04-02 | — | — | US | disclosed |
| EP-3492455-B1 | 1,2,4-TRIAZOLES AS NUCLEAR TRANSPORT MODULATORS AND USE IN THE TREATMENT OF SPECIFIC FORMS OF CANCER | KARYOPHARM THERAPEUTICS INC (US) | 2023-05-17 | — | — | EP | disclosed |
| US-20220177445-A1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | Karyopharm Therapeutics Inc. | 2022-06-09 | — | — | US | disclosed |
| US-11124493-B2 | Nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2021-09-21 | — | — | US | disclosed |
| US-20200199099-A1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | Karyopharm Therapeutics Inc. | 2020-06-25 | — | — | US | disclosed |
| US-10407405-B2 | Nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2019-09-10 | — | — | US | disclosed |
| EP-3492455-A1 | 1,2,4-TRIAZOLES AS NUCLEAR TRANSPORT MODULATORS AND USE IN THE TREATMENT OF SPECIFIC FORMS OF CANCER | Karyopharm Therapeutics Inc. (US) | 2019-06-05 | — | — | EP | disclosed |
| EP-3010892-B1 | 1,2,4-TRIAZOLES AS NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | KARYOPHARM THERAPEUTICS INC (US) | 2018-12-26 | — | — | EP | disclosed |
| US-20180155317-A1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | Karyopharm Therapeutics Inc. | 2018-06-07 | — | — | US | disclosed |
| US-9738624-B2 | Nuclear transport modulators and uses thereof | Karyopharm Therapeutics Inc. (US) | 2017-08-22 | — | — | US | disclosed |
| US-20160152596-A1 | Nuclear Transport Modulators and Uses Thereof | Karyopharm Therapeutics Inc. (US) | 2016-06-02 | — | — | US | disclosed |
| EP-3010892-A1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | Karyopharm Therapeutics, Inc. (US) | 2016-04-27 | — | — | EP | disclosed |
| WO-2014205389-A1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | Karyopharm Therapeutics Inc. (US) | 2014-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220177445-A1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | XPO1, XPO5, XPOT | XPO1 1/4885RANBP1 159/4885KCNH2 4379/4885 |
| US-11945794-B2 | Nuclear transport modulators and uses thereof | XPO1, XPO5, XPOT | XPO1 1/4885RANBP1 159/4885KCNH2 4379/4885 |
| US-20180155317-A1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | XPO1, XPO5, XPOT | XPO1 1/4885RANBP1 159/4885KCNH2 4379/4885 |
| US-10407405-B2 | Nuclear transport modulators and uses thereof | XPO1, XPO5, XPOT | XPO1 1/4885RANBP1 159/4885KCNH2 4379/4885 |
| US-12577225-B2 | Nuclear transport modulators and uses thereof | XPO1, XPOT, CSE1L | XPO1 1/4885RANBP1 321/4885KCNH2 4591/4885 |
| US-11124493-B2 | Nuclear transport modulators and uses thereof | XPO1, XPO5, XPOT | XPO1 1/4885RANBP1 159/4885KCNH2 4379/4885 |
| US-20160152596-A1 | Nuclear Transport Modulators and Uses Thereof | XPO5, XPO1, XPOT | XPO1 2/4885RANBP1 144/4885KCNH2 4320/4885 |
| US-20250059158-A1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | XPO1, XPO5, XPOT | XPO1 1/4885RANBP1 159/4885KCNH2 4379/4885 |
| US-20200199099-A1 | NUCLEAR TRANSPORT MODULATORS AND USES THEREOF | XPO1, XPO5, XPOT | XPO1 1/4885RANBP1 159/4885KCNH2 4379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.