Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.43 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | TTK | P33981 | 1/20 | 0.38 |
| ▸ | JUN | P05412 | 2/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634397 | 0.89 | MAPK10 (0.59) | FGFR1KDRFGFR2MAPK10SIGMAR1 | |
| SCHEMBL1634203 | 0.88 | MAPK10 (0.48) | FGFR1KDRFGFR2MAPK10SIGMAR1 | |
| SCHEMBL1631565 | 0.88 | MAPK10 (0.48) | FGFR1KDRFGFR2MAPK10SIGMAR1 | |
| SCHEMBL1633357 | 0.86 | MAPK10 (0.47) | FGFR1KDRFGFR2MAPK10SIGMAR1 | |
| SCHEMBL1634890 | 0.84 | MAPK10 (0.47) | KDRFGFR2MAPK10MAP3K11JUN | |
| SCHEMBL1633913 | 0.82 | JAK3 (0.48) | FGFR1KDRFGFR2MAPK10CSF1R | |
| SCHEMBL1633364 | 0.82 | KDR (0.45) | KDRFGFR2MAPK10MAP3K11POLB | |
| SCHEMBL1633503 | 0.81 | MAPK10 (0.47) | FGFR1KDRFGFR2MAPK10MAP3K11 | |
| SCHEMBL1632057 | 0.81 | GBA1 (0.45) | FGFR1KDRFGFR2MAPK10JUN | |
| SCHEMBL1631314 | 0.81 | CTSC (0.45) | KDRFGFR2MAPK10POLBJUN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |