Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 6/20 | 0.51 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | LCK | P06239 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 3/20 | 0.40 |
| ▸ | GAK | O14976 | 2/20 | 0.39 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.38 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
| ▸ | MET | P08581 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332000 | 0.91 | BRAF (0.53) | BRAFKDRLCKMAPK14IGF1R | |
| SCHEMBL16331454 | 0.89 | BRAF (0.49) | BRAFKDRLCKMAPK14IGF1R | |
| SCHEMBL16332025 | 0.88 | PTK2 (0.52) | BRAFKDRLCKMAPK14IGF1R | |
| SCHEMBL16331745 | 0.87 | BRAF (0.42) | BRAFKDRLCKMAPK14IGF1R | |
| SCHEMBL16332767 | 0.87 | MAPK9 (0.45) | MAPK14MEN1KMT2AEGFRCDK2 | |
| SCHEMBL16331298 | 0.86 | PIK3CA (0.44) | BRAFIGF1RALDH1A1MAPTMEN1 | |
| SCHEMBL16332766 | 0.82 | PIK3CA (0.44) | BRAFIGF1RALDH1A1MAPTMEN1 | |
| SCHEMBL16331795 | 0.81 | BRAF (0.43) | BRAFKDRLCKMAPK14PTK2 | |
| SCHEMBL16332689 | 0.81 | MEN1 (0.51) | BRAFKDRLCKIGF1RPTK2 | |
| SCHEMBL16331677 | 0.80 | BRAF (0.45) | BRAFKDRLCKMAPK14IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |