Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 10/20 | 0.73 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.67 |
| ▸ | DYRK2 | Q92630 | 10/20 | 0.67 |
| ▸ | DYRK1B | Q9Y463 | 10/20 | 0.67 |
| ▸ | DYRK3 | O43781 | 9/20 | 0.67 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.67 |
| ▸ | CDK5R1 | Q15078 | 6/20 | 0.67 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.67 |
| ▸ | CDK9 | P50750 | 5/20 | 0.67 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.67 |
| ▸ | CDK2 | P24941 | 5/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2951225 | 0.87 | FYN (0.69) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL2951228 | 0.87 | FYN (0.69) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL2946453 | 0.85 | FYN (0.79) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL2947495 | 0.85 | FYN (0.77) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL20485745 | 0.85 | FYN (1.00) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL2947491 | 0.85 | FYN (0.77) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL20485748 | 0.85 | FYN (1.00) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL2946043 | 0.84 | FYN (0.79) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL2941590 | 0.83 | FYN (0.75) | FYNDYRK1ADYRK2DYRK1BDYRK3 | |
| SCHEMBL2942563 | 0.83 | FYN (0.74) | FYNDYRK1ADYRK2DYRK1BDYRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9458463-B2 | Method for treatment of diabetes by a small molecule inhibitor for GRK5 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2016-10-04 | — | — | US | claimed |
| EP-2818471-A1 | Nitrogen bicyclic compounds as inhibitors for Scyl1 and Grk5 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818471-A1 | Nitrogen bicyclic compounds as inhibitors for Scyl1 and Grk5 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |