Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.52 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.47 |
| ▸ | BRAF | P15056 | 7/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | PRKCG | P05129 | 1/20 | 0.43 |
| ▸ | PRKCB | P05771 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | PRKCA | P17252 | 1/20 | 0.43 |
| ▸ | PRKCH | P24723 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 1/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.43 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | IGF1R | P08069 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332292 | 0.91 | BRAF (0.47) | PTK2BRAFLCKKMT2AIGF1R | |
| SCHEMBL16332223 | 0.87 | SMN1; SMN2 (0.44) | TGFBR1BRAFKMT2AALDH1A1IGF1R | |
| SCHEMBL16331319 | 0.86 | FYN (0.47) | KMT2AALDH1A1MEN1LMNA | |
| SCHEMBL16332487 | 0.85 | CYP3A4 (0.51) | KMT2AALDH1A1IGF1REGFRMEN1 | |
| SCHEMBL16332211 | 0.83 | GRIN1 (0.43) | KMT2AMEN1LMNA | |
| SCHEMBL16332390 | 0.82 | GRIN1 (0.43) | ALDH1A1GAAEGFRSMN1; SMN2CREBBP | |
| SCHEMBL16331809 | 0.82 | IGF1R (0.42) | TGFBR1BRAFKMT2AALDH1A1IGF1R | |
| SCHEMBL16332120 | 0.81 | PTK2 (0.49) | PTK2TGFBR1BRAFPRKD3PRKCG | |
| SCHEMBL16331960 | 0.80 | CSF1R (0.46) | KMT2AALDH1A1GAAIGF1RCDK2 | |
| SCHEMBL16570980 | 0.79 | PTK2 (0.71) | PTK2TGFBR1BRAFPRKD3PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | claimed |
| EP-2818472-A1 | Imidazo[4,5-c]pyridine and pyrrolo[3,2-c]pyridine compounds as G-protein-coupled receptor kinase 5 (GRK5) modulators | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) | 2014-12-31 | — | — | EP | disclosed |