Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.67 |
| ▸ | JAK1 | P23458 | 5/20 | 0.67 |
| ▸ | TYK2 | P29597 | 5/20 | 0.67 |
| ▸ | JAK3 | P52333 | 5/20 | 0.67 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.54 |
| ▸ | CHEK1 | O14757 | 7/20 | 0.47 |
| ▸ | SYK | P43405 | 2/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12724448 | 0.88 | JAK2 (0.71) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1635098 | 0.88 | JAK2 (0.74) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633815 | 0.84 | JAK2 (0.54) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633545 | 0.84 | JAK2 (0.65) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633224 | 0.84 | JAK2 (0.65) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1634192 | 0.83 | JAK2 (0.64) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1634409 | 0.81 | JAK2 (0.65) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1632625 | 0.81 | JAK2 (0.62) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1634109 | 0.81 | JAK2 (0.67) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1632720 | 0.81 | JAK2 (0.64) | JAK2JAK1TYK2JAK3TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |