Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 3/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.51 |
| ▸ | CDK9 | P50750 | 2/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.51 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12724942 | 0.93 | MARK3 (0.49) | SYKRIPK2CDK2CCNT1CDK9 | |
| SCHEMBL1633417 | 0.91 | MAPK10 (0.57) | SYKCDK2CCNE1JAK2TBK1 | |
| SCHEMBL1633170 | 0.90 | MAP4K1 (0.49) | SYKCDK2CCNT1CDK9JAK2 | |
| SCHEMBL1633360 | 0.87 | RIPK2 (0.49) | SYKRIPK2CDK2CCNT1CDK9 | |
| SCHEMBL1634798 | 0.85 | SYK (0.53) | SYKCDK2CCNE1JAK2TBK1 | |
| SCHEMBL1634297 | 0.84 | SYK (0.52) | SYKCDK2CCNE1JAK2MAPK10 | |
| SCHEMBL12724944 | 0.84 | MARK3 (0.46) | RIPK2CDK2CCNT1CDK9CCNE1 | |
| SCHEMBL1633613 | 0.83 | JAK2 (0.61) | SYKRIPK2CDK2CCNT1CDK9 | |
| SCHEMBL12724910 | 0.81 | SYK (0.49) | SYKJAK2JAK1JAK3 | |
| SCHEMBL1633219 | 0.81 | SYK (0.49) | SYKJAK2NTRK1JAK1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |