Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 8/20 | 0.52 |
| ▸ | JAK1 | P23458 | 5/20 | 0.52 |
| ▸ | JAK3 | P52333 | 5/20 | 0.52 |
| ▸ | TYK2 | P29597 | 2/20 | 0.52 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 6/20 | 0.45 |
| ▸ | BRD2 | P25440 | 3/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.45 |
| ▸ | BRDT | Q58F21 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 2/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.40 |
| ▸ | CCND1 | P24385 | 2/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1634250 | 0.89 | JAK2 (0.56) | JAK2JAK1JAK3TYK2TNIK | |
| SCHEMBL1634973 | 0.87 | JAK2 (0.54) | JAK2JAK1JAK3TYK2TNIK | |
| SCHEMBL1634131 | 0.87 | JAK2 (0.58) | JAK2JAK1JAK3TYK2TNIK | |
| SCHEMBL1633875 | 0.84 | JAK2 (0.59) | JAK2JAK1JAK3TYK2TNIK | |
| SCHEMBL1632384 | 0.81 | PTK2 (0.61) | JAK2JAK1JAK3TYK2TNIK | |
| SCHEMBL1633157 | 0.81 | JAK2 (0.58) | JAK2JAK1JAK3TYK2TNIK | |
| SCHEMBL1632928 | 0.81 | JAK2 (0.54) | JAK2JAK1JAK3TYK2TNIK | |
| SCHEMBL1632728 | 0.81 | JAK2 (0.59) | JAK2JAK1JAK3TYK2TNIK | |
| SCHEMBL1634663 | 0.80 | PTK2 (0.59) | JAK2JAK1JAK3TYK2TNIK | |
| SCHEMBL1632204 | 0.79 | JAK2 (0.59) | JAK2JAK1JAK3TYK2TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |