Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16332992 | 1.00 | MEN1 (0.41) | MEN1KMT2ATSHRMAPK1CHRM1 | |
| SCHEMBL16332991 | 1.00 | MEN1 (0.41) | MEN1KMT2ATSHRMAPK1CHRM1 | |
| SCHEMBL16333180 | 1.00 | MEN1 (0.41) | MEN1KMT2ATSHRMAPK1CHRM1 | |
| SCHEMBL880061 | 0.89 | MEN1 (0.44) | MEN1KMT2ATSHRMAPK1SLC6A2 | |
| SCHEMBL21458667 | 0.89 | MEN1 (0.44) | MEN1KMT2ATSHRMAPK1SLC6A2 | |
| SCHEMBL23267863 | 0.89 | MEN1 (0.44) | MEN1KMT2ATSHRMAPK1SLC6A2 | |
| SCHEMBL16334063 | 0.88 | — | — | |
| SCHEMBL2146704 | 0.88 | — | — | |
| SCHEMBL2146710 | 0.88 | — | — | |
| Hydrochloric Acid SCHEMBL848878 | 0.87 | MEN1 (0.42) | MEN1KMT2ATSHRMAPK1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013812-A2 | KAPPA OPIOID AGONISTS AND USES THEREOF | Nektar Therapeutics (US) | 2016-05-04 | — | — | EP | disclosed |
| WO-2014210436-A2 | KAPPA OPIOID AGONISTS AND USES THEREOF | NEKTAR THERAPEUTICS (US) | 2014-12-31 | — | — | WO | disclosed |