Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 17/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16333149 | 0.90 | NOTUM (0.66) | NOTUMKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16332773 | 0.83 | NOTUM (0.72) | NOTUMKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16333112 | 0.81 | NOTUM (0.79) | NOTUMKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16333241 | 0.81 | NOTUM (0.69) | NOTUMKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL438058 | 0.81 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL438060 | 0.80 | NOTUM (0.77) | NOTUMCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL16333168 | 0.80 | NOTUM (0.67) | NOTUMKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16333203 | 0.78 | NOTUM (0.65) | NOTUMKDM4EMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16333332 | 0.78 | NOTUM (1.00) | NOTUMCSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL16332999 | 0.78 | NOTUM (0.64) | NOTUMKDM4EMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616471-B1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2014-12-31 | — | — | EP | disclosed |