Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 12/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | PRNP | P04156 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL441103 | 0.86 | NOTUM (1.00) | NOTUMMAP3K8 | |
| SCHEMBL439326 | 0.85 | NOTUM (0.57) | NOTUMALDH1A1RXFP1RAB9AKDM4E | |
| SCHEMBL440686 | 0.84 | NOTUM (0.56) | NOTUMALDH1A1RXFP1RAB9AKDM4E | |
| SCHEMBL16333015 | 0.83 | NOTUM (0.65) | NOTUMALDH1A1RXFP1HPGDPOLB | |
| SCHEMBL16332835 | 0.83 | NOTUM (0.72) | NOTUMALDH1A1RXFP1HPGDPOLB | |
| SCHEMBL16333525 | 0.82 | NOTUM (0.75) | NOTUMALDH1A1RXFP1MAP3K8POLB | |
| SCHEMBL16333308 | 0.82 | NOTUM (0.76) | NOTUMALDH1A1RXFP1RAB9AKDM4E | |
| SCHEMBL441076 | 0.82 | NOTUM (0.54) | NOTUMALDH1A1RXFP1RAB9AKDM4E | |
| SCHEMBL469141 | 0.82 | NOTUM (0.54) | NOTUMALDH1A1RXFP1RAB9AKDM4E | |
| SCHEMBL16333067 | 0.81 | NOTUM (0.69) | NOTUMALDH1A1RXFP1HPGDPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2616471-B1 | INHIBITORS OF NOTUM PECTINACETYLESTERASE AND METHODS OF THEIR USE | LEXICON PHARMACEUTICALS INC (US) | 2014-12-31 | — | — | EP | disclosed |