Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 3/20 | 0.47 |
| ▸ | JUN | P05412 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CDK4 | P11802 | 7/20 | 0.43 |
| ▸ | CCND1 | P24385 | 6/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CDK1 | P06493 | 4/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633430 | 0.92 | MAPK10 (0.48) | MAPK10JUNMAPK8CDK4CCND1 | |
| SCHEMBL1633436 | 0.89 | MAPK10 (0.50) | MAPK10JUNMAPK8CDK4CCND1 | |
| SCHEMBL1633276 | 0.88 | EGFR (0.50) | MAPK10JUNMAPK8CDK4CCND1 | |
| SCHEMBL1632436 | 0.85 | CDK4 (0.47) | MAPK10JUNMAPK8CDK4CCND1 | |
| SCHEMBL1868218 | 0.85 | MAPK10 (0.53) | MAPK10JUNMAPK8CDK4CCND1 | |
| SCHEMBL1634946 | 0.84 | STK17A (0.45) | CYP1A2AURKAJAK2TBK1MYLK4 | |
| SCHEMBL1632467 | 0.84 | IGF1R (0.49) | MAPK10CDK4CCND1CDK2CDK1 | |
| SCHEMBL1633838 | 0.84 | MAPK10 (0.51) | MAPK10JUNMAPK8CDK4CCND1 | |
| SCHEMBL13336221 | 0.81 | MAP4K1 (0.42) | EGFRIGF1RJAK2FGFR1PDGFRB | |
| SCHEMBL1633457 | 0.80 | EGFR (0.40) | MAPK10JUNMAPK8CDK4CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |