Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 3/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
| ▸ | JAK1 | P23458 | 2/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | STK4 | Q13043 | 1/20 | 0.40 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632764 | 0.89 | BRD4 (0.51) | EGFRJAK2BRD4MAPK10CDK1 | |
| SCHEMBL1633266 | 0.84 | BRAF (0.52) | MAP4K4MTORSMG1IKBKBCA2 | |
| SCHEMBL1632623 | 0.84 | MAPK10 (0.53) | EGFRJAK2BRD4MAPK10CDK2 | |
| SCHEMBL1632787 | 0.82 | JAK2 (0.45) | EGFRJAK2BRD4MAPK10CDK1 | |
| SCHEMBL1633437 | 0.80 | JAK2 (0.54) | EGFRJAK2MAPK10CDK1CDK2 | |
| SCHEMBL13498295 | 0.79 | MTOR (0.62) | EGFRJAK2BRD4MAPK10CDK1 | |
| SCHEMBL13498361 | 0.79 | JAK2 (0.49) | JAK2BRD4CDK1CDK2CDK9 | |
| SCHEMBL1633214 | 0.79 | MAPK10 (0.50) | EGFRJAK2BRD4MAPK10CDK1 | |
| SCHEMBL1633187 | 0.78 | MTOR (0.60) | EGFRJAK2BRD4MAPK10CDK2 | |
| SCHEMBL1633524 | 0.78 | JAK2 (0.50) | EGFRJAK2BRD4IKBKBTYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |