Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 10/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.48 |
| ▸ | NOD2 | Q9HC29 | 6/20 | 0.44 |
| ▸ | JAK2 | O60674 | 4/20 | 0.43 |
| ▸ | JAK3 | P52333 | 2/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.43 |
| ▸ | JUN | P05412 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.42 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1632922 | 0.92 | JAK2 (0.48) | RIPK2ACVR1NOD2JAK2JAK3 | |
| SCHEMBL1633630 | 0.88 | MAPK10 (0.45) | MAPK10JUNFGFR2 | |
| SCHEMBL1631565 | 0.87 | MAPK10 (0.48) | JAK2MAPK10JUNFGFR2BRD4 | |
| SCHEMBL1634890 | 0.87 | MAPK10 (0.47) | JAK2MAPK10JUNFGFR2BRD4 | |
| SCHEMBL1633364 | 0.86 | KDR (0.45) | MAPK10JUNFGFR2 | |
| SCHEMBL1632057 | 0.86 | GBA1 (0.45) | JAK2JAK3PTK2MAPK10JUN | |
| SCHEMBL1632629 | 0.86 | MAPK10 (0.44) | JAK2JAK3MAPK10JUNSRC | |
| SCHEMBL1633149 | 0.85 | CA1 (0.48) | JAK2MAPK10SRCFGFR2BRD4 | |
| SCHEMBL1631314 | 0.84 | CTSC (0.45) | JAK3MAPK10JUNSRCFGFR2 | |
| SCHEMBL1631425 | 0.84 | MAOB (0.42) | JAK2MAPK10JUNSRCFGFR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |