Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.49 |
| ▸ | SRC | P12931 | 16/20 | 0.49 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.48 |
| ▸ | YES1 | P07947 | 1/20 | 0.48 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.48 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1633500 | 0.99 | MAP4K1 (0.50) | MAP4K1SRCPDGFRBYES1EPHB4 | |
| SCHEMBL1635169 | 0.95 | SRC (0.49) | MAP4K1SRCPDGFRBYES1EPHB4 | |
| SCHEMBL1631322 | 0.94 | MAP4K1 (0.53) | MAP4K1SRCPDGFRBYES1EPHB4 | |
| SCHEMBL12725113 | 0.91 | MAP4K1 (0.53) | MAP4K1SRCPDGFRBYES1EPHB4 | |
| SCHEMBL12725121 | 0.90 | MAP4K1 (0.53) | MAP4K1SRCPDGFRBYES1EPHB4 | |
| SCHEMBL12725107 | 0.85 | MAP4K1 (0.52) | MAP4K1SRCPDGFRBYES1EPHB4 | |
| SCHEMBL12725118 | 0.85 | MAP4K1 (0.57) | MAP4K1SRCPDGFRBYES1EPHB4 | |
| SCHEMBL12725109 | 0.83 | MAP4K1 (0.51) | MAP4K1SRCPDGFRBYES1EPHB4 | |
| SCHEMBL1633220 | 0.82 | MAP4K1 (0.51) | MAP4K1MAP4K3 | |
| SCHEMBL1632107 | 0.77 | MAP4K1 (0.67) | MAP4K1MAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |