Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.49 |
| ▸ | JAK1 | P23458 | 2/20 | 0.49 |
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | MERTK | Q12866 | 4/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.45 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.45 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 4/20 | 0.44 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CDK4 | P11802 | 2/20 | 0.43 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.43 |
| ▸ | CCND1 | P24385 | 2/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12724051 | 0.92 | JAK2 (0.48) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633848 | 0.87 | JAK2 (0.60) | JAK2JAK1TYK2JAK3MERTK | |
| SCHEMBL1632073 | 0.87 | CDK4 (0.57) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1631022 | 0.86 | JAK2 (0.54) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633947 | 0.85 | MAPK10 (0.58) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1633043 | 0.83 | JAK2 (0.55) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1634187 | 0.83 | JAK2 (0.57) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL1632322 | 0.83 | HRH3 (0.47) | MERTKAXLTYRO3CDK2CCNT1 | |
| SCHEMBL1632549 | 0.82 | JAK2 (0.54) | JAK2JAK1TYK2JAK3TNIK | |
| SCHEMBL12724803 | 0.82 | JAK1 (0.57) | JAK2JAK1TYK2JAK3TNIK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |