Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 5/20 | 0.48 |
| ▸ | CDK1 | P06493 | 5/20 | 0.48 |
| ▸ | CDK9 | P50750 | 5/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 4/20 | 0.48 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.48 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.48 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.48 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.48 |
| ▸ | AXL | P30530 | 4/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 4/20 | 0.46 |
| ▸ | MERTK | Q12866 | 4/20 | 0.46 |
| ▸ | IKBKB | O14920 | 3/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.44 |
| ▸ | TTK | P33981 | 1/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13498360 | 0.89 | CCNT1 (0.52) | JAK2CDK2CDK1CDK9CCNT1 | |
| SCHEMBL1633718 | 0.85 | CDK2 (0.66) | JAK2CDK2CDK1CDK9CCNT1 | |
| SCHEMBL1570569 | 0.82 | CDK2 (0.48) | CDK2CDK1CDK9CCNT1CCNB1 | |
| SCHEMBL1633220 | 0.82 | MAP4K1 (0.51) | CDK2CDK1CDK9CCNT1CCNB1 | |
| SCHEMBL1634357 | 0.80 | AXL (0.43) | JAK2CDK2CDK1CDK9CCNT1 | |
| SCHEMBL1631112 | 0.79 | IKBKB (0.59) | CDK2CDK1CDK9CCNT1CCNB1 | |
| SCHEMBL1633372 | 0.78 | IKBKB (0.53) | CDK2CDK1CDK9CCNT1CCNB1 | |
| SCHEMBL1633248 | 0.78 | IKBKB (0.53) | CDK2CDK1CDK9CCNT1CCNB1 | |
| SCHEMBL1632977 | 0.78 | IKBKB (0.53) | JAK2CDK2CDK1CDK9CCNT1 | |
| SCHEMBL1633475 | 0.77 | MAPK10 (0.53) | CDK2CDK1CDK9CCNT1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |
| US-7932262-B2 | Quinazolines for PDK1 inhibition | NOVARTIS AG (CH) | 2011-04-26 | — | — | US | disclosed |